Norton Healthcare Home
Decrease (-) Restore Default Increase (+)
Bookmark and Share
clear spacerConditions & Services

Amyotrophic lateral sclerosis (ALS)

What is ALS?

Amyotrophic lateral sclerosis (ALS), also referred to as Lou Gehrig’s disease, is a progressive motor neuron disease affecting the nerve cells in the brain and spinal cord. Motor neurons are small bundles of nerves that run from the brain to the spinal cord, then from the spinal cord to the muscles throughout the body.

The progressive degeneration of the motor neurons causes them to die, and the brain loses the connection with the muscle. The result is a lack of muscle control. This “disconnection” then causes the muscle to lose neuron nourishment and stimulation, resulting in muscle atrophy (becoming smaller).


In about 10 percent of cases, ALS is caused by an inherited genetic defect. In all other cases, the cause is unknown. ALS currently affects about five out of every 100,000 people worldwide.

There is no known risk factor for ALS, except for having a family member who has had the hereditary form of the disease. The biological mechanisms that cause ALS are only partially understood and may be due to a particular gene called SOD1. A mutation in this gene is thought to make a protein that is toxic to the motor nerve cells. Due to the accumulation of this toxin, people with ALS progressively lose the ability to function and care for themselves. They no longer have voluntary control over their muscles and eventually lose involuntary control that is required for vital organ systems.


The ALS Multidisciplinary Clinic specializes in the care and treatment of individuals living with amyotrophic lateral sclerosis (ALS) or primary lateral sclerosis (PLS). The clinic staffs a multidisciplinary team of health care professionals from the ALS Association and Norton Neuroscience Institute. Mark P. Bazant, M.D., a neurologist specializing in the care of ALS patients, directs the clinic and its operations. The goal of the clinic is to provide optimal care, support and quality of life for patients who have been diagnosed with either ALS or PLS.

To learn more, or schedule an appointment, please call (502) 899-6782


Mark P. Bazant, M.D., neurologist
Sage Bailey, respiratory therapist
Katherine Dally, speech-language pathologist
Rusty Mattingly, occupational therapist
Laura Miller, physical therapist
Regina Wiseman, pulmonary technologist



The initial onset of ALS, symptoms may be so slight that they are frequently overlooked. Most symptoms develop later in adulthood, usually after age 50. However, they can occur in younger people. People who experience ALS have a loss of muscle strength and coordination that gradually gets worse. Muscle weakness may occur in hands, arms or legs or the muscles that control speech, swallowing and breathing. Often the early signs include twitching and muscle cramps, especially in the hands and feet. These signs can vary significantly from person to person. Symptoms often begin with tripping or falling spells. For others, symptoms begin with slurred speech or episodes of crying or laughing. Difficulty lifting items, buttoning clothes or walking are also common signs.

Muscle weakness is the hallmark sign in ALS, occurring in approximately 60 percent of patients. As the disease begins to worsen, it spreads to the trunk muscles of the body. This leads to dysfunction or weakening of speech, swallowing, chewing and breathing. When breathing muscles become affected, the patient will require permanent ventilator support to survive. These signs represent the end stage of the disease process.


To date, there is no one test or procedure to ultimately diagnose ALS. It is through a physical examination and diagnostic testing, often to rule out other diseases that mimic ALS, that a diagnosis can be made.

The physical exam usually includes an extensive strength and endurance exam. This will assess the patient’s degree of muscle weakness throughout the body. This may show weakness beginning in a particular area, muscle tremors, spasms, twitching or atrophy. A patient with ALS may even have an abnormal gait (or be stiff or have a clumsy walk). Reflexes are often abnormal in that they will be increased at the joint and reduced in the gag reflex. Some patients may have trouble controlling episodes of crying or laughing, often called “emotional incontinence.”

Comprehensive diagnostic testing may be done at the discretion of the physician. These tests may include:

  • Neurological exam
  • Electromyography (EMG) and nerve conduction velocity (NCV)
  • Blood and urine studies
  • Spinal tap
  • X-rays, including magnetic resonance imaging (MRI)
  • Myelogram of the cervical spine
  • Muscle and/or nerve biopsy


At this time, there is no treatment that will cure or slow down the progression of ALS. There are medications that will help with symptoms, along with palliative care to improve comfort.

Medical Care

Pregnancy & Prenatal Classes
Weight Loss
Heart Disease
Women's Health
More Medical Care


Immediate Care
Health Centers
Emergency Room
Doctors Offices
Affiliate Hospitals

Patients and Visitors

Pay Your Bill
Request an Appointment
Get Healthy
Support Groups
Fitness Groups
Mobile Applications
Clinical Trials
Online Nursery
Classes and Events
Send an eCard
Patient Stories
Patient and Family Advisory Council
Places to Stay
Say Thanks
My Health Risk Assessment

About Us

Quality Report 
Ways to Help
Community Outreach
Contact Us
(502) 629-1234

Connect with us

© 2015 Norton Healthcare
Serving Kentucky and Southern Indiana