Brucellosis is an infectious disease that occurs from contact with animals carrying Brucella bacteria.
Cyprus fever; Undulant fever; Gibraltar fever; Malta fever; Mediterranean fever
Brucella can infect cattle, goats, camels, dogs, and pigs. The bacteria can spread to humans if you come in contact with infected meat or the placenta of infected animals, or if you eat or drink unpasteurized milk or cheese.
Brucellosis is rare in the United States. About 100 - 200 cases occur each year.
People working in jobs where they often come in contact with animals or meat -- such as slaughterhouse workers, farmers, and veterinarians -- are at higher risk.
Acute brucellosis may begin with mild flu-like symptoms, or symptoms such as:
Loss of appetite
High fever spikes usually occur every afternoon. The name "undulant" fever is because the fever rises and falls in waves.
Call for an appointment with your health care provider if:
You develop symptoms of brucellosis
Your symptoms get worse or do not improve with treatment
You develop new symptoms
Drinking and eating only pasteurized milk and cheeses is the most important way to reduce the risk of brucellosis. People who handle meat should wear protective glasses and clothing and protect skin breaks from infection.
Detecting infected animals controls the infection at its source. Vaccination is available for cattle, but not humans.
Franco MP, Mulder M, Gilman RH, Smits HL. Human brucellosis. Lancet Infect Dis. 2007;7:775-86.
Young EJ. Brucella Species. In: Mandell GL, Bennett JE, Dolin R, eds. Principles and Practice of Infectious Disease. 7th ed. Philadelphia, PA: Elsevier Churchill Livingstone; 2009:chap 226.
Jatin M. Vyas, MD, PhD, Assistant Professor in Medicine, Harvard Medical School; Assistant in Medicine, Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Bethanne Black, and the A.D.A.M. Editorial team.