Osmotic diuresis is increased urination due to the presence of certain substances in the fluid filtered by the kidneys. This fluid eventually becomes urine. These substances cause additional water to come into the urine, increasing its amount.
Osmotic diuresis can be caused by:
High blood sugar (glucose)
Use of certain medications, such as Mannitol
Kamel KS, Davids MR, Lin S-H, Halperin ML. Interpretation of electrolyte and acid-base parameters in blood and urine. In: Taal MW, Chertow GM, Marsden PA, et al., eds. Brenner & Rector's The Kidney. 9th ed. Philadelphia, PA: Saunders Elsevier; 2011:chap 26.
Landry DW, Bazari H. Approach to the patient with renal disease. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine. 24th ed. Philadelphia, PA: Saunders Elsevier; 2011:chap 116.
Laura J. Martin, MD, MPH, ABIM Board Certified in Internal Medicine and Hospice and Palliative Medicine, Atlanta, GA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.