Osmotic diuresis is increased urination due to the presence of certain substances in the fluid filtered by the kidneys. This fluid eventually becomes urine. These substances cause additional water to come into the urine, increasing its amount.
Osmotic diuresis can be caused by:
High blood sugar (glucose)
Use of certain medications, such as Mannitol
Landry DW, Bazari H. Approach to the patient with renal disease. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine.24th ed. Philadelphia, PA: Saunders Elsevier; 2011:chap 116.
Kamel KS, Davids MR, Lin S-H, Halperin ML. Interpretation of electrolyte and acid-base parameters in blood and urine. In: Taal MW, Chertow GM, Marsden PA, Skorecki K, Yu ASL. Brenner BM, eds. Brenner & Rector's The Kidney. 9th ed. Philadelphia, PA: Saunders Elsevier; 2011:chap 26.
Linda J. Vorvick, MD, Medical Director and Director of Didactic Curriculum, MEDEX Northwest Division of Physician Assistant Studies, Department of Family Medicine, UW Medicine, School of Medicine, University of Washington. Also reviewed by David Zieve, MD, MHA, Bethanne Black, and the A.D.A.M. Editorial team.