Scrofula is a
tuberculous infection of the lymph nodes in the neck.
Causes, incidence, and risk factors
Scrofula in adults is most often caused by the bacteria
Mycobacterium tuberculosis. In children, can also be caused by Mycobacterium scrofulaceum or Mycobacterium avium.
Infection with mycobacteria is usually caused by breathing in air that is contaminated by these organisms.
Symptoms Signs and tests
Tests to diagnose scrofula include:
Biopsy of affected tissue
CT scan of the neck
Cultures to check for the bacteria in tissue samples taken from the lymph nodes
HIV blood test
Other tests for TB Treatment
When infection is caused by
Mycobacterium tuberculosis, treatment usually involves 9 - 12 months of antibiotics. Several antibiotics need to be used at once. Common antibiotics for scrofula include:
When infection is caused by another type of mycobacteria (which often occurs in children), treatment usually involves antibiotics such as rifampin, ethambutol, and clarithromycin.
Surgery is sometimes used first. It may also be used if medications are not working.
With treatment, patients usually make a complete recovery.
Complications Draining sore in the neck
Scarring Calling your health care provider
Call your health care provider if your child has a swelling or group of swellings in the neck. Scrofula can occur in children who have not been exposed to someone with tuberculosis.
People who have been exposed to someone with tuberculosis of the lungs should have a PPD test.
Ellner JJ. Tuberculosis. In: Goldman L, Schafer AI, eds.
Cecil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 332.
Fitzgerald DW, Sterling TR, Haas DW. Mycobacterium tuberculosis. In: Mandell GL, Bennett JE, Dolin R, eds.
Principles and Practice of Infectious Diseases. 7th ed. Philadelphia, Pa: Elsevier Churchill Livingstone; 2009:chap 250.
David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Jatin M. Vyas, MD, PhD, Assistant Professor in Medicine, Harvard Medical School; Assistant in Medicine, Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M. Health Solutions, Ebix, Inc.
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