Decrease (-) Restore Default Increase (+)
Bookmark and Share

Health Library

Back to MainBack to Main   Print This Page Print    Email to a Friend Email
 

Serum sickness

Definition

Serum sickness is a reaction that is similar to an allergy. The immune system reacts to medications that contain proteins used to treat immune conditions. Or it can react to antiserum, the liquid part of blood that contains antibodies given to a person to help protect them against germs or poisonous substances.

Causes

Plasma is the clear fluid portion of blood. It does not contain blood cells. But it does contain many proteins, including antibodies, which are formed as part of the immune response to protect against infection.

Antiserum is produced from the plasma of a person or animal that has immunity against an infection or poisonous substance. Antiserum may be used to protect a person who has been exposed to a germ he or she has not been vaccinated against.

For example, you may receive a certain type of antiserum injection if you have been exposed to tetanus or rabies. This is called passive immunization. It gives you immediate, but temporary, protection while your body develops an active immune response against the toxin or germ.

During serum sickness, the immune system falsely identifies a protein in antiserum as a potentially harmful substance (antigen). The result is an immune system response that attacks the antiserum. Immune system elements and the antiserum combine to form immune complexes, which cause the inflammation and other symptoms of serum sickness.

Certain medications (such as penicillin, cefaclor, and sulfa) can cause a similar reaction. Unlike other drug allergies, which occur very soon after receiving the medication, serum sickness develops 7 to 21 days after the first exposure to a medication.

Injected proteins such as antithymocyte globulin (used to treat organ transplant rejection) and rituximab (used to treat immune disorders and cancers) can cause serum sickness reactions.

Blood products may also cause serum sickness.

Symptoms

Symptoms of serum sickness can include:

  • Fever
  • General ill feeling
  • Hives
  • Itching
  • Joint pain
  • Rash
  • Swollen lymph nodes

Symptoms usually do not develop until 7 to 21 days after the first dose of antiserum or exposure to the medication. However, some people may develop symptoms in 1 to 3 days if they have already been exposed to the substance.

Exams and Tests

The lymph nodes may be enlarged and tender to the touch. The urine may contain blood or protein. Blood tests may show immune complexes or signs of blood vessel inflammation.

Treatment

Corticosteroid creams or ointments or other soothing skin medications may relieve discomfort from itching and a rash.

Antihistamines may shorten the length of the illness and help ease a rash and itching.

Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen or naproxen may relieve joint pain. However, NSAIDs should be used carefully because of the risk for kidney damage. Corticosteroids taken by mouth (such as prednisone) may be prescribed for severe cases.

The medicine that caused the problem should be stopped. Avoid using that medication or antiserum in the future.

Outlook (Prognosis)

The symptoms usually go away within a few days.

Possible Complications

If you use the drug or antiserum that caused serum sickness again in the future, your risk of having another similar reaction is high.

Complications include:

  • Anaphylactic shock, an immediate, life-threatening reaction
  • Inflammation of the blood vessels
  • Swelling of the face, arms, and legs (angioedema)

When to Contact a Medical Professional

Call your health care provider if you have received medication or antiserum in the last 4 weeks and you have symptoms of serum sickness.

Prevention

There is no known way to prevent the development of serum sickness.

People who have experienced serum sickness, anaphylactic shock, or drug allergy should avoid future use of the antiserum or drug.

References

Salmon JE. Mechanisms of immune mediated tissue injury. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine. 24th ed. Philadelphia, PA: Elsevier Saunders; 2012:chap 46.


Review Date: 5/10/2014
Reviewed By: Stuart I. Henochowicz, MD, FACP, Associate Clinical Professor of Medicine, Division of Allergy, Immunology, and Rheumatology, Georgetown University Medical School, Washington, DC. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
adam.com
 

Medical Care

Cancer
Pregnancy & Prenatal Classes
Weight Loss
Orthopedics
Heart Disease
Neurology
Women's Health
More Medical Care

Locations

Hospitals
Immediate Care
Health Centers
Emergency Room
Doctors Offices
Specialists
Affiliate Hospitals

Patients and Visitors

MyChart
Pay Your Bill
Request an Appointment
Get Healthy
Support Groups
Fitness Groups
Mobile Applications
Clinical Trials
Online Nursery
Classes and Events
Send an eCard
Patient Stories
Places to Stay
Say Thanks

About Us

Quality Report 
Careers
Ways to Help
Community Outreach
Contact Us
(502) 629-1234

Connect with us

© 2014 Norton Healthcare
Serving Kentucky and Southern Indiana