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HPV - Human Papillomavirus

HPV Testing from ThinPrep Vials

HPV is the most common sexually transmitted virus. HPV DNA is found in 99.8 percent of cervical carcinomas. Infection with high-risk HPV types strongly predicts subsequent cervical squamous intra-epithelia lesions. Recent data from the ALTS study indicate HPV testing to be an effective strategy in the management and triage of women with Pap smear results of ASC-US (atypical squamous cells of undetermined significance).

CPA Lab offers testing for HPV from the ThinPrep vial. HPV testing can be ordered directly (performed regardless of Pap smear diagnosis) or as a “reflex” test following diagnosis of ASC-US. The combination of ThinPrep liquid-based technology with Cervista’s HPV HR DNA test provides state-of-the-art screening for cervical cancer.

The Cervista HPV test uses signal amplification and fluorescence detection to identify the presence of highly oncogenic types of the HPV virus. CPA Lab tests for high-risk HPV DNA only, which detects HPV types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66 and 68. These high-risk types are a major factor in the development of cervical cancer.

The turnaround time on HPV testing is five to seven days.


HPV 16/18 Genotyping

CPA Lab is now offering the Cervista HPV 16/18 Genotyping as a triage for women with negative cytology and positive high-risk HPV results. This test helps to stratify which women 30 years and older will need immediate colposcopy. The American Society For Colposcopy And Cervical Pathology (ASCCP) recommendations for HPV 16/18 detection are given below. (Include attached HPV 16/18 Genotyping Algorithm.)

For additional information regarding ASCCP guidelines visit http://www.asccp.org/Home/tabid/5809/Default.asp

The turn-around time on HPV 16/18 testing is 5-7 days from receipt of sample.


According to the National Cancer Institute, cervical cancer is almost always caused by human papillomavirus (HPV) infection. But how about a vaccine that wipes out specific HPV strains that account for 75 percent of all cervical cancer cases? A vaccine is available to do that, however, either girls and women aren't getting vaccinated or they're not getting the three shots that are required. Get Healthy's Jackie Hays talks with an expert about the importance of this vaccine for young women as well as for young men.


Reference:
ASCCP "Algorithm for using HPV genotyping for HPV 16 and 18 to triage high-risk HPV positive/ cytology negative women." http://www.asccp.org/Home/tabid/5809/Default.asp. ASCCP, 2/8/2010. "Web." 5/6/2011.

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